Knowledge-Based Avoidance of Drug-Resistant HIV Mutants
DOI:
https://doi.org/10.1609/aimag.v20i1.1437Abstract
We describe an AI system (CTSHIV) that connects the scientific AIDS literature describing specific human immunodeficiency virus (HIV) drug resistances directly to the customized treatment strategy of a specific HIV patient. Rules in the CTSHIV knowledge base encode knowledge about sequence mutations in the HIV genome that have been found to result in drug resistance to the HIV virus. Rules are applied to the actual HIV sequences of the virus strains infecting the specific patient undergoing clinical treatment to infer current drug resistance. A rule-directed search through mutation sequence space identifies nearby drug-resistant mutant strains that might arise. The possible combination drug-treatment regimens currently approved by the U.S. Food and Drug Administration are considered and ranked by their estimated ability to avoid identified current and nearby drug-resistant mutants. The highest-ranked treatments are recommended to the attending physician. The result is more precise treatment of individual HIV patients and a decreased tendency to select for drug-resistant genes in the global HIV gene pool. Initial results from a small human clinical trial are encouraging, and further clinical trials are planned. From an AI viewpoint, the case study demonstrates the extensibility of knowledge-based systems because it illustrates how existing encoded knowledge can be used to support new knowledge-based applications that were unanticipated when the original knowledge was encoded.Downloads
Published
1999-03-15
How to Cite
Lathrop, R. H., Steffen, N. R., Raphael, M. P., Deeds-Rubin, S., Pazzani, Michael J., Cimoch, P. J., See, D. M., & Tilles, J. G. (1999). Knowledge-Based Avoidance of Drug-Resistant HIV Mutants. AI Magazine, 20(1), 13. https://doi.org/10.1609/aimag.v20i1.1437
Issue
Section
Articles
License
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Authors who publish with this journal agree to the following terms:
- The author(s) warrants that they are the sole author and owner of the copyright in the above article/paper, except for those portions shown to be in quotations; that the article/paper is original throughout; and that the undersigned right to make the grants set forth above is complete and unencumbered.
- The author(s) agree that if anyone brings any claim or action alleging facts that, if true, constitute a breach of any of the foregoing warranties, the author(s) will hold harmless and indemnify AAAI, their grantees, their licensees, and their distributors against any liability, whether under judgment, decree, or compromise, and any legal fees and expenses arising out of that claim or actions, and the undersigned will cooperate fully in any defense AAAI may make to such claim or action. Moreover, the undersigned agrees to cooperate in any claim or other action seeking to protect or enforce any right the undersigned has granted to AAAI in the article/paper. If any such claim or action fails because of facts that constitute a breach of any of the foregoing warranties, the undersigned agrees to reimburse whomever brings such claim or action for expenses and attorneys’ fees incurred therein.
- Author(s) retain all proprietary rights other than copyright (such as patent rights).
- Author(s) may make personal reuse of all or portions of the above article/paper in other works of their own authorship.
- Author(s) may reproduce, or have reproduced, their article/paper for the author’s personal use, or for company use provided that original work is property cited, and that the copies are not used in a way that implies AAAI endorsement of a product or service of an employer, and that the copies per se are not offered for sale. The foregoing right shall not permit the posting of the article/paper in electronic or digital form on any computer network, except by the author or the author’s employer, and then only on the author’s or the employer’s own web page or ftp site. Such web page or ftp site, in addition to the aforementioned requirements of this Paragraph, must provide an electronic reference or link back to the AAAI electronic server, and shall not post other AAAI copyrighted materials not of the author’s or the employer’s creation (including tables of contents with links to other papers) without AAAI’s written permission.
- Author(s) may make limited distribution of all or portions of their article/paper prior to publication.
- In the case of work performed under U.S. Government contract, AAAI grants the U.S. Government royalty-free permission to reproduce all or portions of the above article/paper, and to authorize others to do so, for U.S. Government purposes.
- In the event the above article/paper is not accepted and published by AAAI, or is withdrawn by the author(s) before acceptance by AAAI, this agreement becomes null and void.