Interpretable Machine Learning for In-Home Mild Cognitive Impairment Detection

Abstract

This paper introduces a novel system for in-home cognitive health assessment using ambient sensors and a machine learning technology that can robustly detect mild cognitive impairment (MCI) despite limited available data. The learned model can explain the aspects of individuals' daily lives led to the prediction, while reliably predicting MCI, providing more insights to healthcare workers for further clinical interventions. We developed the robust transparent machine learning model, based on fusion adaptive resonance theory (Fusion ART) neural network to learn individuals' daily patterns of activity from continuous sensor data in terms of a suite of digital biomarkers reflecting four key domains: physical, daily activity, cognitive engagement, and sleep patterns. Based on a longitudinal study of over one hundred participants, deployed with non-intrusive sensors in their homes to undergo parallel clinical evaluation across a period of five years, our model successfully identified individuals with MCI, achieving high predictive accuracy regardless the noisy and sparse availability of data. As a transparent neural network, the learned model can also be interpreted as classification rules to distinguish MCI from normal cognition (NC) cases based on the digital biomarkers. These results demonstrate that passively collected, sensor-derived digital biomarkers can be leveraged to indicate cognitive status and potentially providing clinically meaningful insights on the impairment conditions. We also discuss the practical challenges and lessons learned from this real-world deployment to inform future large-scale implementations of such AI-driven health monitoring systems.